Water-soluble SHPs as novel alkylating agents

US6855695B2 · kind B2 · utility

Assignee

• Vion Pharmaceuticals, Inc. · US

Inventors

• Xu Lin · Branford, US
• Terrence W. Doyle · Fayetteville, US
• Ivan King · North Haven, US

Key dates

• Filing date: Jun 13, 2003
• Grant date: Feb 15, 2005
• Expiry date: Jun 29, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R′ is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OPO3H2, NO2, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and R6 are, independently H, F, Cl, Br, I, OH, OPO3H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SF5, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5 or R6 are other than H, the other two of unassigned groups of R2, R3, R4, R5 or R6 are H. R7 is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.