Process for isolating conjugated estrogens
US6855704B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 9, 2002 |
| Grant date | Feb 15, 2005 |
| Priority date | — |
| Expiry date | Mar 25, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a process for extracting conjugated estrogens from pregnant mare urine. The present invention further relates to a process for obtaining a natural mixture of conjugated estrogens. The mixture of conjugated estrogens can be used to prepare products for estrogen replacement therapy or hormone replacement therapy. More specifically, the process for extracting conjugated estrogens from PMU comprises the steps of (a) contacting a mare urine material (MUM) with a resin to adsorb phenolic components, (b) contacting the phenolics-depleted MUM of step (a) with a resin to adsorb the stone and equilin, the major estrogen components, (c) containing the major estrogen-depleted MUM of step (b) with a resin to adsorb the minor estrogen components, (d) separately desorbing the major estrogen components and the minor estrogen components from the resins used in steps (b) and (c), and (e) separately treating the desorbed material form step (d) to obtain crystals of the major estrogen components and the minor estrogen components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.