Patent · US Expired

Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs

US6855710B2 · kind B2 · utility

6Cited by

0References

9Claims

0Family size

Assignee

BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

Rainer Walter · Biberach, DE
Wolfgang Grell · Biberach, DE
Armin Heckel · Biberach an der Riß, DE
Frank Himmelsbach · Mittelbiberach, DE
Wolfgang Eberlein · Biberach, DE
Gerald Juergen Roth · Biberach, DE
Jacobus Van Meel · Biberach, DE
Norbert Redemann · Biberach, DE
Walter Spevak · Stockerau, AT
Ulrike Tontsch-Grunt · Baden, AT
Thomas von Rueden · Planegg, DE

Key dates

Filing date	Sep 19, 2003
Grant date	Feb 15, 2005
Priority date	—
Expiry date	Sep 19, 2023

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to new substituted indolinones of general formula wherein The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.