Ligands directed to the non-secretory component, non-stalk region of plgR and methods of use thereof

US6855810B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Keith E. Mostov · San Francisco, US
• Steven J. Chapin · San Diego, US
• Janice Richman-Eisenstat · Winnipeg, CA

Key dates

• Filing date: Mar 26, 2001
• Grant date: Feb 15, 2005
• Expiry date: Jun 4, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.