17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds

US6855836B2 · kind B2 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Bernd Menzenbach · Jena, DE
• Peter Droescher · Weimar, DE
• Walter Elger · Berlin, DE
• Alexander Hillisch · Solingen, DE
• Gunter Kaufmann · Jena, DE
• Hans-Udo Schweikert · Bonn, DE
• Gerd Muller · Jena, DE

Key dates

• Filing date: Sep 27, 2001
• Grant date: Feb 15, 2005
• Expiry date: Dec 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J13/007
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to 17-methylene steroids, process for their production and pharmaceutical compositions that contain these compounds.The compounds according to the invention have a hybrid-type profile of action in the sense that they act as inhibitors of 5α-reductase and simultaneously as gestagens. They are therefore suitable for treating diseases that are the result of elevated androgen levels in certain organs and tissues in men and women. Together with other hormonal substances, such as an estrogen, testosterone or a strong androgen, the compounds according to the invention are suitable as contraceptive agents for women and for men.