Method for synthesis, separation and screening of a plurality of compounds in the same bulk of a stationary phase
US6858434B1 · kind B1 · utility
16Cited by
11References
36Claims
0Family size
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Key dates
| Filing date | Oct 6, 2000 |
| Grant date | Feb 22, 2005 |
| Priority date | — |
| Expiry date | Oct 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for sequentially performing a synthesis, separation and screening of chemical entities, especially a combinatorial library, is described. The method utilises a bulk of a stationary phase (e.g. silica gel, aluminium oxide, cellulose, etc. for example arranged on a backing) for the performance of the synthesis, separation and screening. The technique described enables a rapid route from synthesis to the testing of chemical compounds. Screening can be performed without need for reaction work-up. Preferred screening methods are those used to determine the biological activity of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.