Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

US6858580B2 · kind B2 · utility

Assignee

• Nobex Corporation · US

Inventors

• Nnochiri Ekwuribe · Cary, US
• Christopher H. Price · Chapel Hill, US
• Aslam M. Ansari · Rockville, US
• Amy L. Odenbaugh · Morrisville, US

Key dates

• Filing date: Jun 4, 2001
• Grant date: Feb 22, 2005
• Expiry date: Jun 4, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/6093
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.