Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera

US6858588B2 · kind B2 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Suman Preet Singh Khanuja · Lucknow, IN
• Jai Shanker Arya · Lucknow, IN
• Ranganathan Tiruppadiripuliyur · Lucknow, IN
• Dharmendra Saikia · Lucknow, IN
• Harpreet Kaur · Brampton, CA
• Monika Singh · Lucknow, IN
• Subhash Chandra Gupta · Lucknow, IN
• Ajit Kumar Shasany · Sidhauli, IN
• Mahendra Pandurang Darokar · Lucknow, IN
• Santosh Kumar Srivastava · Lucknow, IN
• Madan Mohan Gupta · Sidhauli, IN
• Subash Verma · Lucknow, IN
• Anirban Pal · Lucknow, IN

Key dates

• Filing date: Mar 31, 2003
• Grant date: Feb 22, 2005
• Expiry date: Mar 31, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.