Use of tetrahydropteridine derivatives as no synthase inhibitors

US6858612B1 · kind B1 · utility

Assignee

• Vasopharm Buitech GmbH · DE

Inventors

• Wolfgang Pfleiderer · Konstanz, DE
• Harald Schmidt · Wallisellen, CH
• Rainer Henning · Tokyo, JP

Key dates

• Filing date: Jul 20, 1999
• Grant date: Feb 22, 2005
• Expiry date: Jul 20, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of pteridine derivatives of the formula I in which X is O or NH and R4, for example, is hydrogen, phenyl or the radical R4a—CH2— and R4a, for example, is hydrogen, (C1-C4)-alkylmercapto, the radical —NR11R12 or the radical —OR13, and in which R1, R2, R3, R5, R6, R7, R11, R12 and R13 have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.