Substituted 2-arylbenzazole compounds and their use as antitumour agents
US6858633B1 · kind B1 · utility
13Cited by
2References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 21, 2000 |
| Grant date | Feb 22, 2005 |
| Priority date | — |
| Expiry date | Jan 10, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/2208
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the benzene ring of the benzazole nucleus has a halogen substituent, preferably flourine, and the 2-phenyl group has a 4′-amino substituent which may be conjugated with an amino acid to provide a water soluble amino acid amide prodrug or salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.