Substituted indolinones

US6858641B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Gerald Juergen Roth · Biberach, DE
• Armin Heckel · Biberach an der Riß, DE
• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Joerg Kley · Mittelbiberach, DE
• Frank Hilberg · Wien, AT
• Jacobus Van Meel · Biberach, DE

Key dates

• Filing date: Apr 4, 2002
• Grant date: Feb 22, 2005
• Expiry date: Apr 4, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to indolinones substituted in the 6-position of general formula whereinR1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various, pharmaceutical compositions containing these compounds, their use and processes for preparing them.