Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
US6861045B1 · kind B1 · utility
Inventors
Key dates
| Filing date | Sep 8, 2000 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Nov 6, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/106
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.