Preparation method of biodegradable porous polymer scaffolds having an improved cell compatibility for tissue engineering
US6861087B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 16, 2002 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Dec 22, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/56
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for modifying surface of biodegradable porous polymer scaffold for tissue engineering using a low temperature plasma discharge apparatus, and particularly, a method for inducing the biodegradable porous polymer scaffold to be hydrophilic by graft polymerizing a hydrophilic monomer on the surface of the biodegradable porous polymer scaffold, which is made of polylactic acid, polyglycolic acid or poly(lactic acid-glycolic acid) copolymer, using a low temperature plasma. The surface-modified porous polymer scaffold according to the present invention has an enhanced cell compatibility in cell culture in vitro, and promote tissue growth when the cell is transplanted into a body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.