Stabilization of implantable bioprosthetic devices
US6861211B2 · kind B2 · utility
98Cited by
12References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 22, 2001 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Aug 22, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention relates to methods of stabilizing glycosaminoglycans in a biological tissue (e.g. a bioprosthetic implant) in conjunction with cross-linking of protein in the tissue. The methods of the invention improve the mechanical integrity of the device and improves its stability in vivo. The invention also includes biological tissues having stabilized glycosaminoglycans and cross-linked proteins and kits for preparing such tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.