Export and modification of (poly)peptides in the lantibiotic way
US6861236B2 · kind B2 · utility
31Cited by
23References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 7, 2003 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Feb 7, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intracellular posttranslational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether-containing peptides and dehydroalanine/dehydrobutyrine-containing.peptides, wherein thioether rings may be formed extracellularly.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.