L-lysine-producing corynebacteria and process for the preparation of lysine

US6861246B2 · kind B2 · utility

Assignee

• Degussa AG · DE

Inventors

• Caroline Kreutzer · Melle, DE
• Bettina Mockel · Bielefeld, DE
• Walter Pfefferle · Bodenwerder, DE
• Lothar Eggeling · Jülich, DE
• Hermann Sahm · Jülich, DE
• Miroslav Patek · Praha, CZ

Key dates

• Filing date: Mar 19, 2001
• Grant date: Mar 1, 2005
• Expiry date: Mar 19, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/77
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to L-lysine-producing strains of corynebacteria with enhanced pyc gene (pyruvate carboxylase gene), in which strains additional genes, chosen from the group consisting of the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the lysE gene (lysine export carrier gene) and the dapB gene (dihydrodipicolinate reductase gene), but especially the dapA gene, are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.