Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor

US6861254B1 · kind B1 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Robert D. Rosenberg · Brookline, US
• Nicholas W. Shworak · Westwood, US
• Jian Liu · Chapel Hill, US
• Linda M. S. Fritze · Sharon, US
• John Schwartz · Bensenville, US
• Lijuan Zhang · Beacon, US

Key dates

• Filing date: Apr 24, 2000
• Grant date: Mar 1, 2005
• Expiry date: Apr 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/20
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are novel isolated nucleic acids and substantially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glicosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.