1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
US6861523B2 · kind B2 · utility
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Key dates
| Filing date | Feb 8, 2002 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Apr 25, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.