Solution phase sythesis of arylbenzoxazoles
US6861533B2 · kind B2 · utility
3Cited by
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6Claims
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Key dates
| Filing date | Nov 19, 2002 |
| Grant date | Mar 1, 2005 |
| Priority date | — |
| Expiry date | Nov 19, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. The resulting arylbenzoxazoles can be separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion exchange resin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.