Oncoprotein protein kinase

US6863888B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael Karin · Village of La Jolla, US
• Masahiko Hibi · San Diego, US
• Anning Lin · Village of La Jolla, US
• Roger J. Davis · Princeton, US
• Benoit Derijard · Nice, FR

Key dates

• Filing date: May 18, 2001
• Grant date: Mar 8, 2005
• Expiry date: Jun 25, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.