Polypeptides from CREB binding protein and related protein p300 for use in transcriptional regulation
US6864054B1 · kind B1 · utility
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Key dates
| Filing date | May 26, 1999 |
| Grant date | Mar 8, 2005 |
| Priority date | — |
| Expiry date | May 26, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.