Therapeutic agents useful for treating pain

US6864261B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Parviz Gharagozloo · Pennington, US
• Khondaker Islam · Arlington, US
• Donald J. Kyle · Yardley, US
• Qun Sun · Princeton, US
• Laykea Tafesse · Robinsville, US
• John William Frank Whitehead · Carbondale, US
• Ji Yang · Jingwei, CN
• Xiaoming Zhou · Plainsboro, US

Key dates

• Filing date: May 2, 2003
• Grant date: Mar 8, 2005
• Expiry date: Jun 11, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (wherein A, R1, R2, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Piperazine Compound”); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.