Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
US6864355B1 · kind B1 · utility
19Cited by
5References
22Claims
0Family size
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Key dates
| Filing date | Aug 22, 2000 |
| Grant date | Mar 8, 2005 |
| Priority date | — |
| Expiry date | Jul 8, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes compositions and methods for the selective inhibition of cytokine-mediated NF-κB activation by blocking the interaction of NEMO with IκB kinase-β (IKKβ) at the NEMO binding domain (NBD). The blockade of IKKβ-NEMO interaction resulting in inhibition of IKKβ kinase activity and subsequent decreased phosphorylation of IκB. Phosphorylation of IκB being an integral step in cytokine-mediated NF-κB activation. The invention further includes methods for screening for agents capable of interacting at the NBD and therapeutic uses for such agents in pathological disorders caused by dysregulation of NF-κB activation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.