Composite nanospheres and their conjugates with biomolecules

US6866838B1 · kind B1 · utility

Assignees

• BIOMERIEUX, INC. · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Olivier Mondain-Monval · Bordeaux, FR
• Abdelhamid Elaissari · Val-de-Reuil, FR
• Eric Bosc · Gujan-Mestras, FR
• Christian Pichot · Saint-Germain-en-Laye, FR
• Bernard Mandrand · Villeurbanne, FR
• Jerome Bibette · Bordeaux, FR

Key dates

• Filing date: Nov 6, 2000
• Grant date: Mar 15, 2005
• Expiry date: Jun 15, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2987
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.