Spliced gene of KSHV/HHV8, its promoter and monoclonal antibodies specific for LANA2

US6866854B1 · kind B1 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuan Chang · New York, US
• Patrick S. Moore · New York, US

Key dates

• Filing date: Sep 5, 2003
• Grant date: Mar 15, 2005
• Expiry date: Sep 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid which encodes a Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 polypeptide (LANA2) or a fragment thereof and also provides the LANA2 polypeptide. This invention provides an isolated nucleic acid comprising consecutive nucleotides having the sequence of a promoter of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 transcription. This invention also provides a method of inhibiting p53 mediated apoptosis of a cell and a method of producing an antibody which comprises introducing into a cell a replicable vector of the subject invention.