Peptides that deliver antisense oligonucleotides which downregulate protein expression in cells
US6867043B2 · kind B2 · utility
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1References
26Claims
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Assignee
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Key dates
| Filing date | Nov 2, 2001 |
| Grant date | Mar 15, 2005 |
| Priority date | — |
| Expiry date | Jul 22, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/0041
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a peptide that can complex with an oligonucleotide, e.g. an antisense oligonucleotide, and deliver it into a cell. The present invention also provides compositions comprising a complex of such a peptide and an oligonucleotide and methods of delivering an oligonucleotide into a cell and of inhibiting protein expression using such compositions. The present invention also provides a method of making such a complex, a method of sensitizing cells to anti-cancer agents such as paclitaxel, and pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.