Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith

US6867183B2 · kind B2 · utility

Assignee

• Nobex Corporation · US

Inventors

• Richard Soltero · Holly Springs, US
• Balasingam Radhakrishan · Chapel Hill, US
• Nnochiri Ekwuribe · Cary, US
• Bruce Rehlaender · Chapel Hill, US
• Anthony Hickey · Chapel Hill, US
• Li Li Bovet · Chapel Hill, US

Key dates

• Filing date: Sep 5, 2002
• Grant date: Mar 15, 2005
• Expiry date: Sep 5, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.