Aryl substituted pyrimidines

US6867210B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Derk Hogenkamp · Carlsbad, US
• Phong X. Nguyen · Placentia, US
• Bin Shao · Shanghai, CN

Key dates

• Filing date: Mar 12, 2001
• Grant date: Mar 15, 2005
• Expiry date: Mar 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.