Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors

US6867300B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jollie D. Godfrey, Jr. · Lawrenceville, US
• John Hynes · Washington Crossing, US
• Alaric J. Dyckman · Lawrenceville, US
• Katerina Leftheris · Skillman, US
• Zhongping Shi · Plainsboro, US
• Stephen T. Wrobleski · Whitehouse Station, US
• Wendel W. Doubleday · New Richmond, US
• John A. Grosso · Princeton, US

Key dates

• Filing date: Nov 6, 2002
• Grant date: Mar 15, 2005
• Expiry date: Jan 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.