Process for the synthesis of atorvastatin form v and phenylboronates as intermediate compounds

US6867306B2 · kind B2 · utility

Assignee

• Biocon Ltd. · IN

Inventors

• Sumitra Srinath · Savanuru, IN
• Joy Mathew · Savanuru, IN
• Sandhya Ujire · Savanuru, IN
• Madhavan Sridharan · Savanuru, IN
• Ganesh Sambasivam · Bengaluru, IN

Key dates

• Filing date: Jun 14, 2001
• Grant date: Mar 15, 2005
• Expiry date: Jun 14, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin. The compound so prepared is useful as inhibitor of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agent.