EPOTHILONE SYNTHESIS BUILDING BLOCKS III AND IV: ASYMMETRICALLY SUBSTITUTED ACYLOINS AND ACYLOIN DERIVATIVES, METHODS FOR THEIR PRODUCTION AND METHODS FOR THE PRODUCTION OF EPOTHILONES B, D AND EPOTHILONE DERIVATIVES

US6867333B2 · kind B2 · utility

Assignee

• Morphochem GmbH · DE

Inventors

• Ludger A. Wessjohann · Bodenwerder, DE
• Gunther Scheid · Landshut, DE
• Uwe Bornscheuer · Greifswald, DE
• Erik Henke · New York, US
• Wouter Kuit · Neede, NL
• Romano Orru · Haarlem, NL

Key dates

• Filing date: Apr 15, 2003
• Grant date: Mar 15, 2005
• Expiry date: Apr 15, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.