Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4
US6867334B2 · kind B2 · utility
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14References
2Claims
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Key dates
| Filing date | Oct 3, 2001 |
| Grant date | Mar 15, 2005 |
| Priority date | — |
| Expiry date | Jun 20, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/64
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.