Raman spectroscopy crystallization analysis method
US6867858B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 2003 |
| Grant date | Mar 15, 2005 |
| Priority date | — |
| Expiry date | May 26, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/65
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of monitoring sample crystallization from a solution. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time and under conditions promoting crystallization. Within each of the multiple Raman spectra, a first signal is identified corresponding to the sample associated with the solvent. A second signal corresponding to the sample in a microcrystallite state is also identified. Thereafter, the intensity of the multiple Raman spectra are measured for an increase relating to formation of the sample in a microcrystallite state. A method of monitoring sample crystallization from a solution as a function of turbidity is also disclosed. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time under conditions promoting crystallization. A decrease in intensity is measured across the multiple Raman spectrum over time, the intensity decrease associated with macroscopic crystallization opacity. The decrease in intensity is finely correlated with the onset of macroscopic crystallization of the sample from the solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.