Passivation of nerve agents by surface modified enzymes stabilized by non-covalent immobilization on robust, stable particles

US6869784B2 · kind B2 · utility

Assignee

• The United States of America, as represented by The Secretary of America · US

Inventors

• Alok Singh · Springfield, US
• Mehran Pazirandeh · Silver Spring, US
• Paul E. Schoen · Alexandria, US
• Michael A. Markowitz · Burke, US
• J. Matthew Mauro · Silver Spring, US

Key dates

• Filing date: Nov 29, 2000
• Grant date: Mar 22, 2005
• Expiry date: Nov 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N11/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Enzymes are modified by incorporating anchor sites for linking the enzymes to a target surface without destroying the catalytic activity of the enzymes. A stable carrier to accommodate and bind the selected enzyme is constructed, and the enzyme is non-covalently linked to the carrier, generally through metal salts of iminodiacetate.