Acyl CoA:cholesterol acyltransferase (ACAT-2)

US6869937B1 · kind B1 · utility

Assignees

• The Regents of the University of California · US
• The United States of America as represented by the Department of Veteran Affairs · US

Inventors

• Sylvaine Cases · Belmont, US
• Robert Farese · San Francisco, US
• Sandra K. Erickson · San Francisco, US
• Sabine Novak · Munich, DE
• Michel Accad · San Francisco, US

Key dates

• Filing date: Jun 27, 2000
• Grant date: Mar 22, 2005
• Expiry date: Aug 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/1029
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.