Process for the preparation of 2'-halo-β-L-arabinofuranosyl nucleosides
US6870048B2 · kind B2 · utility
1Cited by
4References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 29, 2002 |
| Grant date | Mar 22, 2005 |
| Priority date | — |
| Expiry date | Mar 29, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to the process for the preparation of 2′-deoxy-2′-halo-β-L-arabinofuranosyl nucleosides, and in particular, 2′-deoxy-2′-fluoro-β-L-arabinofuranosyl thymine (L-FMAU), from L-arabinose, which is commercially available and less expensive than L-ribose or L-xylose, in ten steps. All of the reagents and starting materials are inexpensive and no special equipment is required to carry out the reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.