Specificity in the detection of anti-rubella IGM antibodies
US6872396B2 · kind B2 · utility
0Cited by
14References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 29, 2003 |
| Grant date | Mar 29, 2005 |
| Priority date | — |
| Expiry date | Oct 29, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/56983
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention particularly discloses an improved immunoassay method for the specific detection of anti-rubella IgM antibodies. This method employs rubella antigens comprising rubella E1 and E2 envelope glycoproteins substantially free of capsid protein. Use of this antigen composition reduces or eliminates nonspecific protein-protein interactions leading to false positive results. A sample diluent comprising urea can also be used in the process to further reduce the occurrence of nonspecific protein-protein interactions. A diagnostic kit to aid in the detection of anti-rubella IgM antibodies is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.