E. coli O157:H7 C1 esterase inhibitor-binding protein and methods of use
US6872559B2 · kind B2 · utility
3Cited by
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11Claims
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Assignee
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Key dates
| Filing date | Oct 26, 2001 |
| Grant date | Mar 29, 2005 |
| Priority date | — |
| Expiry date | Feb 15, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933and other enterohemorrhagic E. coli that binds to and cleaves C1-esterase inhibitor. Also disclosed are methods employing the polypeptide for diagnosing and treating colitis or hemolytic uremic syndrome, and methods of detecting potential therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.