Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation

US6872727B1 · kind B1 · utility

Assignee

• Privates Institut fur Biomedizinische Forschung und Beratung · DE

Inventors

• Konrad Herrmann · Leipzig, DE
• Siegfried Leistner · Leipzig, DE
• Petra Wippich · Hamburg, DE

Key dates

• Filing date: Aug 21, 2000
• Grant date: Mar 29, 2005
• Expiry date: Dec 9, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/96
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.