HRPCa9 and HRPCa10 nucleic acids and polypeptides
US6872811B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 30, 1998 |
| Grant date | Mar 29, 2005 |
| Priority date | — |
| Expiry date | Sep 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/136
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns cDNA molecules encoding HRPCa 9 and HRPCa 10 both of which are constitutively expressed in the androgen-independent cell line, LN3 LNAcP and induced by testosterone in the androgen-dependent cell line, LNAcP.The invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention. The invention also provides screening assays which can be used to identify compounds useful for the treatment of prostate cancer (e.g., androgen-independent prostate cancer).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.