Insulin and IGF-1 receptor agonists and antagonists

US6875741B2 · kind B2 · utility

Inventors

• Renuka Pillutla · Bound Brook Junction, US
• Renee Brissette · Clarksburg, US
• Arthur Blume · Annandale, US
• Lauge Schaffer · Copenhagen, DK
• Jakob Brandt · Hjørring, DK
• Neil I. Goldstein · Maplewood, US
• Jane Spetzler · Hjørring, DK
• Søren Østergaard · Copenhagen, DK
• Per Hertz Hansen · Avenue Madeleine, DK

Key dates

• Filing date: Sep 24, 2001
• Grant date: Apr 5, 2005
• Expiry date: Feb 23, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/62
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.