Arylsulfonamide ethers, and methods of use thereof

US6875765B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• James Knobelsdorf · Noblesville, US
• Sheryl Jeanne Hays · Ann Arbor, US
• Charles J. Stankovic · Ann Arbor, US
• Kimberly Para · Ann Arbor, US
• Michael Connolly · Salem, US
• Paul Galatsis · Newton, US
• William Harter · Chelsea, US
• Aurash Shahripour · Rahway, US
• Mark Plummer · Westbrook, US
• Beth Lunney · San Diego, US
• Bernd Janssen · Ludwigshafen, DE
• Jay Bradford Fell · Longmont, US

Key dates

• Filing date: May 10, 2002
• Grant date: Apr 5, 2005
• Expiry date: May 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized structure: and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. In addition, methods of treating stroke, inflammatory diseases, septic shock, repurfusion injury, Alzheimer's disease, and shigellosis, using a compound of the invention or a pharmaceutical composition thereof, are described.