Compounds

US6875777B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• William Brown · Yorba Linda, US
• Christopher Walpole · Mont-Laurier, CA

Key dates

• Filing date: Dec 15, 2000
• Grant date: Apr 5, 2005
• Expiry date: Jan 20, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application is directed to compounds having the structure of Formula I: where R1 is phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl or trazolyl, each optionally substituted by a straight or branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, or iodo;where Ra and Rb are independently selected from hydrogen, a straight or branched C1-C6 alkyl, NO2, C1-C6 alkoxy, chloro, fluoro, bromo, or iodo; and where X is O or CH3.The compounds may be incorporated into pharmaceutical compositions and administered to patients as a treatment for pain, gastrointestinal disorders, spinal injury, or disorders of the sympathetic nervous system.