Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade

US6875791B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Michael S. South · Chesterfield, US
• Chun Ma · Chesterfield, US
• Kevin J. Koeller · Richmond Heights, US
• Hayat Rahman · Belleville, US
• William L. Neumann · Chesterfield, US

Key dates

• Filing date: Apr 4, 2001
• Grant date: Apr 5, 2005
• Expiry date: Apr 4, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/40
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.