Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors

US6875867B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Paul R. Brodfuehrer · Onondaga, US
• Thomas R. Sattelberg, Sr. · Bloomington, US
• Joydeep Kant · Cherry Hill, US
• Xinhua Qian · Flemington, US

Key dates

• Filing date: May 30, 2002
• Grant date: Apr 5, 2005
• Expiry date: Jul 6, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R1a is preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.