Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
US6878363B2 · kind B2 · utility
15Cited by
17References
46Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 17, 2001 |
| Grant date | Apr 12, 2005 |
| Priority date | — |
| Expiry date | May 17, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0468
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.