Fibril-blocking peptide, a method for preventing fibril formation
US6878521B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 2000 |
| Grant date | Apr 12, 2005 |
| Priority date | — |
| Expiry date | Nov 13, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of minimizing the aggregation tendencies of an amyloid forming protein is provided comprising identifying a portion of the protein that is critical to amyloid formation; and inserting a peptide at the portion. The invention also provides a peptide for insertion in an intact human kappa-IV light chain variable domain, the peptide comprising the following amino acid sequence Phe71-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) wherein the subscript numbers are the residue location points in the domain. A method for preventing amyloid formation in human kappa-IV light chain variable domain is also provided, the method comprising inserting the peptide Phe1-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) into the domain, wherein the subscript numbers indicate the residue location on the domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.