Papilloma pseudo-virus and preparation
US6878541B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Nov 14, 2002 |
| Grant date | Apr 12, 2005 |
| Priority date | — |
| Expiry date | Nov 14, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/20061
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.