Synthesis of template-fixed β-hairpin loop mimetics
US6878804B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 30, 1999 |
| Grant date | Apr 12, 2005 |
| Priority date | — |
| Expiry date | Aug 30, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K7/64
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimick flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.