Synthesis of acyclic nucleoside derivatives

US6878844B2 · kind B2 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• M. Robert Leanna · Grayslake, US
• Michael Dolberg Rasmussen · Kenosha, US
• Howard E. Morton · Gurnee, US
• Zhenping Tian · Shandong, CN
• Daniel Plata · Wadsworth, US
• Bradley D. Gates · Mount Prospect, US
• Bikshandarkoil A. Narayanan · Mundelein, US

Key dates

• Filing date: Dec 9, 2002
• Grant date: Apr 12, 2005
• Expiry date: Dec 9, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.